From ruins to reconstruction: past and present

Keynote speech introducing the Session ‘Ancient Cities: Past and Current Perspectives

The EU’s olive oil diplomacy: Italian fears and prospects for Tunisia

On 10 March, the European Parliament voted in favor of a measure allowing Tunisia to export yearly 35,000 tons of olive oil tax-free in the European Union, for two years. That is, Tunisia will be allowed to export to the EU 70,000 tons of olive oil between 2016 and 2017 with no further duties. The decision has attracted much criticism from associations of local farmers, especially in Italy. The Italian Minister of Agricultural Policies, Maurizio Martina, spoke against the decision, because it would damage the Italian olive oil sector. The controversy prompts us to reflect on the policy options the European Union has towards the Southern Mediterranean countries. Furthermore, it shows how much gap there exists at national level between political slogans – even the most populist ones – and concrete action(s)

Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle

Background: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of alpha-dystroglycan. Overexpression of LARGE induces hyperglycosylation of alpha-dystroglycan in both wild type and in cells from dystroglycanopathy patients, irrespective of their primary gene defect, restoring functional glycosylation. Viral delivery of LARGE to skeletal muscle in animal models of dystroglycanopathy has identical effects in vivo, suggesting that the restoration of functional glycosylation could have therapeutic applications in these disorders. Pharmacological strategies to upregulate Large expression are also being explored.Methodology/Principal Findings: In order to asses the safety and efficacy of long term LARGE over-expression in vivo, we have generated four mouse lines expressing a human LARGE transgene. On observation, LARGE transgenic mice were indistinguishable from the wild type littermates. Tissue analysis from young mice of all four lines showed a variable pattern of transgene expression: highest in skeletal and cardiac muscles, and lower in brain, kidney and liver. Transgene expression in striated muscles correlated with alpha-dystroglycan hyperglycosylation, as determined by immunoreactivity to antibody IIH6 and increased laminin binding on an overlay assay. Other components of the dystroglycan complex and extracellular matrix ligands were normally expressed, and general muscle histology was indistinguishable from wild type controls. Further detailed muscle physiological analysis demonstrated a loss of force in response to eccentric exercise in the older, but not in the younger mice, suggesting this deficit developed over time. However this remained a subclinical feature as no pathology was observed in older mice in any muscles including the diaphragm, which is sensitive to mechanical load-induced damage.Conclusions/Significance: This work shows that potential therapies in the dystroglycanopathies based on LARGE upregulation and alpha-dystroglycan hyperglycosylation in muscle should be safe

Analytical and numerical seismic assessment of heritage masonry towers

Abstract The new Italian building code, published in 2018 [MIT in NTC 2018: D.M. del Ministero delle Infrastrutture e dei trasporti del 17/01/2018. Aggiornamento delle Norme Tecniche per le Costruzioni (in Italian), 2018], explicitly refers to the Italian “Guidelines for the assessment and mitigation of the seismic risk of the cultural heritage” [PCM in DPCM 2011: Direttiva del Presidente del Consiglio dei Ministri per valutazione e riduzione del rischio sismico del patrimonio culturale con riferimento alle norme tecniche per le costruzioni, G.U. n. 47 (in Italian), 2011] as a reliable source of guidance that can be employed for the vulnerability assessment of heritage buildings under seismic loads. According to these guidelines, three evaluation levels are introduced to analyse and assess the seismic capacity of historic masonry structures, namely: (1) simplified global static analyses; (2) kinematic analyses based on local collapse mechanisms, (3) detailed global analyses. Because of the complexity and the large variety of existing masonry typologies, which makes it particularly problematic to adopt a unique procedure for all existing structures, the guidelines provide different simplified analysis approaches for different structural configurations, e.g. churches, palaces, towers. Among the existing typologies of masonry structures there considered, this work aims to deepen validity, effectiveness and scope of application of the Italian guidelines with respect to heritage masonry towers. The three evaluation levels proposed by the guidelines are here compared by discussing the seismic risk assessment of a representative masonry tower: the Cugnanesi tower located in San Gimignano (Italy). The results show that global failure modes due to local stress concentrations cannot be identified if only simplified static and kinematic analyses are performed. Detailed global analyses are in fact generally needed for a reliable prediction of the seismic performance of such structures.</jats:p

Unconventional Metallic Magnetism in LaCrSb{3}

Neutron-diffraction measurements in LaCrSb{3} show a coexistence of ferromagnetic and antiferromagnetic sublattices below Tc=126 K, with ordered moments of 1.65(4) and 0.49(4) Bohr magnetons per formula unit, respectively (T=10 K), and a spin reorientation transition at ~95 K. No clear peak or step was observed in the specific heat at Tc. Coexisting localized and itinerant spins are suggested.Comment: PRL, in pres

A goal programming methodology for multiobjective optimization of distributed energy hubs operation

This paper addresses the problem of optimal energy flow management in multicarrier energy networks in the presence of interconnected energy hubs. The overall problem is here formalized by a nonlinear constrained multiobjective optimization problem and solved by a goal attainment based methodology. The application of this solution approach allows the analyst to identify the optimal operation state of the distributed energy hubs which ensures an effective and reliable operation of the multicarrier energy network in spite of large variations of load demands and energy prices. Simulation results obtained on the 30 bus IEEE test network are presented and discussed in order to demonstrate the significance and the validity of the proposed method

Application of artificial dynamics to represent non-isolated single-input multiple-output DC-DC converters with averaged models

This paper presents for the first time the application of a method based on the transformation of the differential algebraic equations of non-isolated Single-Input Multiple Output (SIMO) DC-DC converters into a set of ordinary differential equations, by using artificial dynamics whose asymptotic convergence to the solution is guaranteed by the satisfaction of the relevant Lyapunov conditions. The mathematical formulation is simpler than in other formulations applied in the literature to study non-isolated SIMO DC-DC converters, and encompasses the use of sensitivity functions. The results show that the proposed solution represents in a fully accurate way the dynamics of the averaged models of Zeta Buck-Boost and Cúk Boost Combination converters

New Data on the In Vitro Activity of Fenticonazole against Fluconazole-Resistant Candida Species.

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